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Ibrahim, I.M.; Hasan, M.S.; Elsabaa, K.I.; Elsaie, M.L.
Journal of Cosmetic Dermatology 20(9): 2867-2873
2021
ISSN/ISBN: 1473-2165 PMID: 33544448 DOI:10.1111/jocd.13976Accession:080338181
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Summary
Pumpkin (Cucurbita pepo L.) is an annual climber plant, and its seeds have considerable amount of oil with nutritional and medicinal importance. The present study aimed to investigate the clinical efficacy of pumpkin seed oil (PSO) in the treatment of female pattern hair loss (FPHL) and compare its effects with minoxidil 5% foam. Patients with FPHL were randomly assigned to pumpkin seed oil (n=30; group A) or minoxidil 5% foam (n=30; group B) for a period of 3months. Patients were evaluated clinically and dermoscopically at baseline, at one and half months, and at the end of the 3-month study. Among group A (pumpkin seed oil) candidates, a significant decrease was observed in hair shaft diversity before and after treatment (30.5±6.2%, 24.0±4.02, P<.001, respectively) as well as in the vellus hairs (22.5±4.9, 15.8±2.2, P<.001, respectively). Upright regrowing hairs significantly increased from (0.13±0.5) before treatment to (0.9±1.0) after treatment (P<.001). In group B (minoxidil applying) candidates, a significant decrease was observed in hair shaft diversity before and after treatment (31.5±6.3%, 21.3±2.2, P<.001, respectively) as well as in the vellus hairs (24.7±6.4, 19.5±5.4, P=.02, respectively). Conclusion Findings of the present trial provide evidence of a promising potential role of PSO in treating FPHL.References
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